NSAID
Ketorolac is nonselective. Diclofenac, even though it is older, is COX-2 selective.
Recommended categorization of non-aspirin nonsteroidal anti-inflammatory drugs. The upper dashed line indicates a 2-fold increase in COX-1 selectivity; the lower dashed line indicates a 2-fold increase in COX-2 selectivity. COX, cyclooxygenase; IC50, half-maximal inhibitory concentration; NSAIDs, non-aspirin nonsteroidal anti-inflammatory drugs. Constructed from previously published data.
Bonnesen K, Schmidt M. Recategorization of Non-Aspirin Nonsteroidal Anti-inflammatory Drugs According to Clinical Relevance: Abandoning the Traditional NSAID Terminology. Can J Cardiol. 2021 Nov;37(11):1705-1707.
Recommended categorization of non-aspirin nonsteroidal anti-inflammatory drugs. The upper dashed line indicates a 2-fold increase in COX-1 selectivity; the lower dashed line indicates a 2-fold increase in COX-2 selectivity. COX, cyclooxygenase; IC50, half-maximal inhibitory concentration; NSAIDs, non-aspirin nonsteroidal anti-inflammatory drugs. Constructed from previously published data.
Bonnesen K, Schmidt M. Recategorization of Non-Aspirin Nonsteroidal Anti-inflammatory Drugs According to Clinical Relevance: Abandoning the Traditional NSAID Terminology. Can J Cardiol. 2021 Nov;37(11):1705-1707.
Ibuprofen Liquid Gel
Ketorolac (oral) has the fastest onset. Liquid gel ibuprofen is much faster than the tablet form. Naproxen sodium is slightly slightly slower than ibuprofen liquid gel. Graph is simulated by ChatGPT.
Ketorolac - Oral, Intramuscular, Intravenous, Intransal
Bioavailability 100% by all routes of administration. Tmax about 45 min by oral, IM or intranasal. Data it top table from package insert for ketorolac tromethamine injection.
