NSAID
Ketorolac is nonselective. Diclofenac, even though it is older, is COX-2 selective.
Recommended categorization of non-aspirin nonsteroidal anti-inflammatory drugs. The upper dashed line indicates a 2-fold increase in COX-1 selectivity; the lower dashed line indicates a 2-fold increase in COX-2 selectivity. COX, cyclooxygenase; IC50, half-maximal inhibitory concentration; NSAIDs, non-aspirin nonsteroidal anti-inflammatory drugs. Constructed from previously published data.
Bonnesen K, Schmidt M. Recategorization of Non-Aspirin Nonsteroidal Anti-inflammatory Drugs According to Clinical Relevance: Abandoning the Traditional NSAID Terminology. Can J Cardiol. 2021 Nov;37(11):1705-1707.
Recommended categorization of non-aspirin nonsteroidal anti-inflammatory drugs. The upper dashed line indicates a 2-fold increase in COX-1 selectivity; the lower dashed line indicates a 2-fold increase in COX-2 selectivity. COX, cyclooxygenase; IC50, half-maximal inhibitory concentration; NSAIDs, non-aspirin nonsteroidal anti-inflammatory drugs. Constructed from previously published data.
Bonnesen K, Schmidt M. Recategorization of Non-Aspirin Nonsteroidal Anti-inflammatory Drugs According to Clinical Relevance: Abandoning the Traditional NSAID Terminology. Can J Cardiol. 2021 Nov;37(11):1705-1707.
Ketorolac - Oral, Intramuscular, Intravenous, Intransal
Bioavailability 100% by all routes of administration. Tmax about 45 min by oral, IM or intranasal. Data it top table from package insert for ketorolac tromethamine injection.
